Since 2003, Holy Trinity Church has responded to the mission and service call of the Gospel by sponsoring various local and international mission and outreach projects. Homes were built for needy Mexican families through Project Mexico, various philanthropic projects were undertaken in the Pittsburgh area, and assistance was provided to Native Americans in Montana.

In 2007, members of Holy Trinity Church gathered to work with Hosannah Industries, a local charitable organization to put new siding on the
Carnegie home of a widow and her seriously-ill son. The decades-old compressed cardboard siding was replaced with brand new vinyl siding at no cost to the family. Volunteers learned on the job as they measured, cut and installed the siding.

The missions focus in 2008 was domestic, meeting the needs of the Native American community, much of which is in extreme poverty. Twenty-six teen and adult missionaries from Holy Trinity traveled to Browning, MT as part of the first Young Orthodox Christian American Mission Adventures (YOCAMA) Metropolis Mission Trip to the Blackfoot Indian Reservation. The entire team comprised 116 missionaries, mostly from Greek Orthodox parishes in Pennsylvania and Ohio. The construction-type work done on this trip included building a safety fence at a nursing home, reconstructing a community baseball field, painting a community library, installing handicapped ramps, and various maintenance projects at schools, a hospital and individual homes. The team also assisted in school daycare and athletic programs, visited nursing home residents and shut-ins and provided medical services at a local clinic.

All of these mission projects took a great deal of effort to complete and an endless supply of love of Christ, which calls us to help those in need around us. As we reach out to our fellow man, we reach out unto the Lord. Let us continue to share our resources not only within our community, but with those in need in our greater community of humanity.